A graphic presentation of the study shows anti-inflammatory and anti-allergic effects of xanthones in mangosteen through regulation of the nuclear factor, which is responsible for allergic inflammation in atopic dermatitis.
Mangosteen rind extract (250 mg/kg per day) was administrated to mice, a model for human atopic dermatitis, for 6 weeks to evaluate its preventive effects on atopic dermatitis.
The graph shows the effects of mangosteen rind extract on various immune cell functions.Oral administration of mangosteen rind extract prevented the increase of clinical skin severity scores, plasma total immunoglobulin E levels, scratching behavior, transepidermal water loss and epidermal hyperplasia in mice. No adverse effects were noted.
J Dermatol. 2013 Oct;40(10):786-96. doi: 10.1111/1346-8138.12250. Epub 2013 Aug 21.
Suppressive effect of mangosteen rind extract on the spontaneous development of atopic dermatitis in NC/Tnd mice.
Higuchi H1, Tanaka A, Nishikawa S, Oida K, Matsuda A, Jung K, Amagai Y, Matsuda H.
Recent advances in atopic dermatitis and psoriasis: genetic background, barrier function, and therapeutic targets.
Miyagaki T1, Sugaya M2.